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KMID : 0357919780120040419
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Korean Journal of Pathology
1978 Volume.12 No. 4 p.419 ~ p.426
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Study on Serum Alpha-fetoprotein and Hepatitis B Surface Antigen in Primary Liver Cell Carcinoma in Busan Area
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Abstract
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The authors investigated the frequency of alpha-fetoprotein(AFP) and hepatitis B
surface antigen(HBsAg) in 135 cases of the primary hepatocellular carcinoma, clinically
and pathologically diagnosed in Busan National University Hospital and affiliated
hospitals in Busan during a period of 28 months from June 1976 to September 1978.
Serum AFP was detected by Ouchterlony microimmunodiffusion method and serum
HBsAg was detected by counterimmunoe lectrophoresis.
The results obtained were as follow:
1. Serum AFP was detected in 81(60%) out of 135 cases of primary hepatocellular
carcinoma but were not detected in all cases out of 331 of healthy person and 108 of
other liver diseases.
2. Serum HBsAg was detected in 16(11.9%) out of 135 cases of primary hepatocellular
carcinoma and in 15(4.5%) out of 351 cases of healthy control. The HBsAg postive rate
of the primary hepatocellular carcinoma was significantly higher than that of the healthy
control.
3. The serum HBsAg positive rates between the AFP positive and negative
hepatocellular carcinoma was not significantly different.
4. No influence of sex and age was found between AFP positive and negative
hepatocellular carcinoma and between HBsAg positive and negative hepatocellular
carcinoma between HBsAg positive and negative hepatobellular carcinoma
On the basis mentioned above, it is suggested that there is no correlation between
serum AFP and HBsAg in primary hepatocellular carcinoma.
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